Henry Shirley may refer to:
Henry Shirley (dramatist) (died 1627), English dramatist, murdered by Sir Edward Bishopp, 2nd Baronet Henry Shirley, 3rd Earl Ferrers (1691–1745), English nobleman and lunatic Henry Shirley (diplomat) on List of ambassadors of the United Kingdom to Russia Arthur Shirley (Henry Raymond Shirley, 1886–1967), Australian actor, writer, producer and director Henry G. Shirley (1874–1941), commissioner of the Virginia Department of Highways Sir Henry Shirley, 2nd Baronet (1589–1633), landowner and local politician