Otobius is a genus in the soft-bodied tick family, Argasidae. While similar to the genus Ornithodoros, it is characterized by a vestigial hypostome in adults, despite being developed in nymphs, in addition to the absence of both eyes and hood.

Species Otobius is one of several genera in the Argasid subfamily Ornithodorinae. However, its subfamilial placement has been questioned in Mans et al. 2024. The genus currently contains two species:

O. (Otobius) lagophilus Cooley & Kohls, 1940 O. (Otobius) megnini (Dugès, 1883)

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