Michael Locke may refer to:
Michael Locke (biologist) (1929–2013), English-born Canadian biologist Michael Locke (stuntman) (born 1979), member of the Dirty Sanchez crew Michael K. Locke (1952–2014), American politician Michael Lok (c.1532–c.1621), English merchant and traveller
See also Michael Laucke (born 1947), Canadian guitarist