Iannone is a surname. Notable people with the surname include:
Andrea Iannone (born 1989), Italian motorcycle road racer Bert Iannone (1917–1996), Canadian football player Carol Iannone, conservative writer and literary critic Claudio Iannone (born 1963), Argentine cyclist Dorothy Iannone (1933-2022), American-born visual artist Filippo Iannone (born 1957), Roman Catholic church leader Jamie Iannone, American businessman, CEO of eBay Marvin P. Iannone, American policeman Patrick Iannone (born 1982), Italian ice hockey player Tommaso Iannone (born 1990), Italian rugby player