Mabuza is a Nguni surname popular in South Africa and Eswatini. Notable people with the surname include:
David Mabuza (1960–2025), South African politician Enos John Mabuza (1939–1997), South African politician Jabulani Mabuza (born 1972), Eswatini politician and businessman Kaizer Mabuza (born 1980), South African boxer Lady Howard Mabuza, Eswatini politician Njabulo Mabuza, Eswatini businessman and politician Qinisile Mabuza, Eswatini judge Richard Mabuza (1946–2018), Eswatini long-distance runner Silence Mabuza (born 1977), South African boxer Thabo Mabuza (born 1994), South African rugby player
See also Felicia Mabuza-Suttle, South African television personality