Mike Tyson (born 1966) is an American former boxer.

Mike Tyson or Michael Tyson may also refer to:

Michael Tyson (antiquary) (1740–1780), English clergyman Mike Tyson (baseball) (born 1950), American former baseball player Mike Tyson (American football) (born 1993), American football player Mike Tyson (sprinter), winner of the 1973 4 × 400 meter relay at the NCAA Division I Indoor Track and Field Championships