Columbia Southern may refer to:
Columbia-Southern Chemical Corporation, a heavy industrial chemical company Columbia Southern Hotel, a historic Oregon hotel Columbia Southern Railway, an Oregon rail line Columbia Southern Railway Passenger Station and Freight Warehouse, a historic Oregon building Columbia Southern University, an Alabama for-profit private university specializing in distance education
See also British Columbia Southern Interior, a former British Columbia, Canada electoral district British Columbia Southern Railway, a railway stretching through parts of Canada and the United States