Santee is a surname. Notable people with the surname include:
Corey Santee (born 1983), American basketball player David Santee (born 1957), American figure skater James Santee (born 1962), American figure skater Milton Santee (1835–1901), American civil engineer, surveyor, miner, real estate developer, and entrepreneur Wes Santee (1932–2010), American athlete