Piccolo is an Italian surname. Notable people with the surname include:
Alessandro Piccolo (agricultural scientist) (born 1951), Italian chemist and agricultural scientist Alessandro Piccolo (racing driver) (born 1980), Italian racing driver Antonio Piccolo (born 1988), Italian footballer Antonio Piccolo (footballer, born 1990), Italian footballer Brian Piccolo (1943–1970), American National Football League player Donato Piccolo (born 1976), Italian artist Felice Piccolo (born 1983), Italian footballer Francesco Piccolo (born 1964), Italian writer and screenwriter Francisco María Piccolo (1654–1729), Sicilian Jesuit missionary in Mexico Frank Piccolo (1921-1981), American mobster María Jimena Piccolo (born 1985), Argentine actress Michele Piccolo (born 1985), Italian footballer Ottavia Piccolo (born 1949), Italian theatre and film actress Renato Piccolo (born 1962), Italian former cyclist Rina Piccolo, Canadian cartoonist Rino Piccolo, international film producer and film commissioner Sol Piccolo (born 1996), Argentine female volleyball player Tony Piccolo (born 1960), Australian politician
See also Joseph LoPiccolo (disambiguation) Salvatore Lo Piccolo (born 1942), Sicilian mafioso