Caffyn is a surname that may refer to:
Ben Caffyn (1879–1942), American baseball player Chaloner Caffyn (1891–1917), English ice hockey player Marshall Caffyn (1892–1966), Australian rules footballer Matthew Caffyn (1628–1714), British General Baptist preacher and writer Nancy Caffyn (1934–2010), American politician Paul Caffyn, New Zealand sea kayaker William Caffyn (1828–1919), English cricketer