Saffold is a surname. Notable people with the surname include:
Benjamin F. Saffold (1826–1889), Alabama Supreme Court Justice Monroe Saffold Jr. (born 1948), American body builder Reuben Saffold (1788–1847), Chief Justice of the Supreme Court of Alabama Rodger Saffold (born 1988), American football player Saint Saffold (born 1944), American football player