D'Abruzzo is an Italian surname meaning "of Abruzzo". Notable people with this surname include the following:
Alan Alda (born Alphonso D'Abruzzo, 1936), American actor Robert Alda (born Alphonso D'Abruzzo; 1914–1986), Italian-American actor Stephanie D'Abruzzo (born 1971), American actress and puppeteer
See also Abruzzo (surname)