HSI may refer to:
Government and politics Croatian Syrmian Initiative, a political party in Serbia () Hispanic-serving institution, an American college designation Homeland Security Investigations, an American law enforcement agency Humane Society International, an animal welfare organization
Science and technology HSI color space, in computing Heterosubtypic immunity, in medicine High Speed Interconnect, a computer chip Horizontal shaft impactor, a rock crusher Horizontal situation indicator, an aircraft instrument Hurricane Severity Index Hyperspectral imaging
Sport HSI (track team) Croatian World Games (), multi-sport international event Icelandic Handball Association (, )
Other uses (surname), various Chinese surnames, romanized in Pinyin Hang Seng Index, a stock market index Hastings Municipal Airport, Nebraska, United States Billboard Hot 100, a chart with the shortcut "HSI" Sultan Ismail Hospital, Johor, Malaysia
See also HS1 (disambiguation) ('HS' and the digit '1') Xi (disambiguation) — and are different transliterations of the same sound in Chinese