Hoss is a nickname of:

Bill "Hoss" Allen (1922–1997), American radio disc jockey Hoss Ellington (1935–2014), American NASCAR driver and team owner Hoss Hodgson (1886–1967), American football player and coach Jeff Hostetler (born 1961), former National Football League quarterback Waylon Jennings (1937–2002), American country music singer Hoss Wright, American rock drummer Eric "Hoss" Cartwright, one of the main characters on the TV series Bonanza

See also Old Hoss Radbourn (1854–1897), American professional baseball pitcher Corey Harrison, aka "Big Hoss", from the History Channel's Pawn Stars