De Chambrun is a surname. Notable people with the surname include:
Charles de Chambrun (1875–1952) (1875–1952), French diplomat and writer Clara Longworth de Chambrun (1873–1954), American patron of the arts and scholar of Shakespeare Comtesse Jean-François de Chambrun or Raine Spencer, Countess Spencer (born 1929), British socialite and local politician Pierre de Chambrun (1865–1954), French politician Pineton de Chambrun, French aristocratic family, of which several members have taken an important part in French politics René de Chambrun (1906–2002), lawyer at the Court of Appeals of Paris and of the New York State Bar Association
See also Josée and René de Chambrun Foundation, a non-profit charitable foundation based in Paris, France