Whiffen is an English surname. Notable people with the surname include:
Alma Joslyn Whiffen-Barksdale (1916–1981), American mycologist Blanche Whiffen (1845–1936), American actress David Whiffen (1922–2002), British physicist Kingsley Whiffen (1950–2006), Welsh footballer Marcus Whiffen (1916–2002), English architectural historian
See also Wiffen, a surname