Nikishin () is a Russian masculine surname, its feminine counterpart is Nikishina. It may refer to
Alexander Nikishin (born 2001), Russian hockey player Bohdan Nikishyn (born 1980), Ukrainian fencer Evgenii Nikishin (1945–1986), Russian mathematician Svetlana Nikishina (born 1958), Russian volleyball player Viktoria Nikishina (born 1984), Russian foil fencer Yevgeni Nikishin (1904–1965), Russian football player