Senotherapeutics refers to therapeutic agents/strategies that specifically target cellular senescence.Childs et al. (2015). Cellular senescence in aging and age-related disease: from mechanisms to therapy Nature Medicine Senotherapeutics include emerging senolytic/senoptotic small molecules that specifically induce cell death in senescent cells Chang J., Wang Y.,Shao L. et al., & Zhou D. (2015). Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nature Medicine and agents that inhibit the pro-inflammatory senescent secretome.Xu et al. (2015). JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age PNAS Senescent cells can be targeted for immune clearance, but an ageing immune system likely impairs senescent cell clearance leading to their accumulation.Burton and Faragher (2015). Cellular senescence: from growth arrest to immunogenic conversion AGE Therefore, agents which can enhance immune clearance of senescent cells can also be considered as senotherapeutic.
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