Samatiguila Department is a department of Kabadougou Region in Denguélé District, Ivory Coast. In 2021, its population was 19,710, making it the least-populous department in the country. The departmental seat is the settlement of Samatiguila. The sub-prefectures of the department are Kimbirila-Sud and Samatiguila.

History Samatiguila Department was created in 2009 as a second-level subdivision via a split-off from Odienné Department."Regions of Côte d'Ivoire (Ivory Coast)", statoids.com, accessed 16 February 2016. At its creation, it was part of Denguélé Region.

In 2011, districts were introduced as new first-level subdivisions of Ivory Coast. At the same time, regions were reorganised and became second-level subdivisions and all departments were converted into third-level subdivisions. At this time, Samatiguila Department became part of Kabadougou Region in Denguélé District.

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