SPIS may refer to:
Scottish Police Information Strategy, former name of the Scottish Police Services Authority – Information Communications Technology Pias Airport (ICAO code), Pias, Peru Spiš, a region in north-eastern Slovakia, with a very small area in south-eastern Poland Spiš Castle, one of the largest castle sites in Central Europe Spiš county, an administrative county of the Kingdom of Hungary
See also SPI (disambiguation)