Luzhin () is a Russian family name, derived from the word luzha, "puddle". Its feminine counterpart is Luzhina. It may refer to:
Fyodor Luzhin (died 1727), Russian geodesist and cartographer Luzhin Strait within Kuril Islands, named after Fyodor Luzhin Larisa Luzhina (born 1939), Russian actress
See also The Luzhin Defence