Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system. It has been found to trigger dopamine release in the nucleus accumbens of rats.
Derivatives Phenylbiguanide is used to make amanozineClauder Otto Dr Dipl Ing Chem; Zemplen Bela Dr; Bulcsu Gyula, AT168063 (1951 to Gedeon Richter), C.A. 47, 8097h (1953).Overberger, C. G.; Shapiro, Seymour L. (1954). "Monomer Synthesis.1Triazines. The Reaction of Phenylbiguanide with Ethyl Oxalate and Ethyl Formate". Journal of the American Chemical Society. 76 (1): 93–96. doi:10.1021/ja01630a025. and benfosformin.DE2130303 idem J Anatol, H Vidalenc, G Loiseau, US3769406 (1973 to Ugine Kuhlmann). See also Chlorophenylbiguanide References