De la Fosse is a surname of French origin, and may refer to:
Antoine de La Fosse (c. 1653–1708), French playwright Charles de La Fosse (1636–1716), French painter, uncle to Antoine Charles-Alexandre Coëssin de la Fosse (1829–1910), French painter and engraver Eustache de la Fosse (c. 1451–1523), Flemish-speaking sailor Louis Remy de la Fosse (c. 1659–1726), French architect
See also Arboretum de la Fosse in Fontaine-les-Coteaux, France Delafosse