Mackworth may refer to:
People Humphrey Mackworth (Parliamentarian) (1603–1654) Humphrey Mackworth (1657–1727) Humphrey Mackworth (born 1631)
Places Mackworth, Amber Valley, a village and civil parish in Derbyshire, England Mackworth Castle Mackworth, Derby, a housing estate and ward in the city of Derby, Derbyshire, England