Modugno () is an Italian surname from Apulia. It is likely a toponymic surname derived from the Apulian town of Modugno. People with the name include:
Domenico Modugno (1928–1994), Italian singer, songwriter, actor, and politician Enrica Maria Modugno (born 1958), Italian actress Franco Modugno (born 1938), Italian law professor and judge Giuseppe Modugno (born 1960), Italian pianist Ludovica Modugno (1949–2021), Italian actress and voice actress Raffaella Modugno (born 1988), Italian model
See also 6598 Modugno, a minor planet
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