Preston North End Football Club, an English association football club based in the Deepdale area of Preston, Lancashire, was founded in 1880. For their first eight years, there was no league football, so matches were arranged on an occasional basis, supplemented by cup competitions organised at both local and national level. In 1888, Preston participated in the inaugural Football League. They won the first top-flight league title and of the 22 matches they won 18 and drew the other four, therefore they remained undefeated thus being labelled "The Invincibles". They were the only team to be known by this nickname for 115 years until Arsenal completed their 2003–04 season without a defeat. Since then the club has remained in the Football League although it has competed in its various divisions.

Preston North End's record against each club faced league competition is listed below. Preston's first league game was against Burnley in the inaugural 1888–89 Football League. They met their 109th and most recent different league opponent, Burton Albion, for the first time in the 2016–17 EFL Championship season. The team that Preston North End has met most in league competition is Burnley, against whom they have contested 128 league matches; having won 52 of these Burnley are also the side Preston have beaten the most. Preston have tied 33 games with Bolton Wanderers, they are the team that they have drawn with the most. The team that has defeated Preston the most is Aston Villa, who have won 51 of their 104 encounters with Preston.

Key The table includes results of matches played by Preston North End in the English Football League (1888–present) For the sake of simplicity, present-day names are used throughout: for example, results against Newton Heath, Small Heath and Woolwich Arsenal are integrated into the records against Manchester United, Birmingham City and Arsenal, respectively Teams with this background and symbol in the "Club" column are competing in the 2023–24 EFL Championship alongside Preston Clubs with this background and symbol in the "Club" column are defunct P = matches played; W = matches won; D = matches drawn; L = matches lost; F = goals for; A = goals against; Win% = percentage of total matches won The columns headed "First" and "Last" contain the first and most recent seasons in which Preston played league matches against each opponent

All-time league record Statistics correct as of matches played on 19 October 2024.

+Preston North End F.C. league record by opponentClubHomeAwayTotalWin%FirstLastNote(s)P W D LP W D LP W D L F AAccrington 5320 5320 1888–891892–93Aldershot 621361321974–751988–89Arsenal361871136610201901–021960–61Aston Villa522612145296371888–892018–19Barnet210120021994–951995–96Barnsley2816572887131901–022021–22Birmingham City4827147481211251894–952023–24Blackburn Rovers 52271411521615211888–892024–25Blackpool4525713451511191901–022022–23Bolton Wanderers62252017622313261888–892018–1915645155281974–752021–22Bradford City291210729710121903–042014–15Bradford Park Avenue10334106221912–131949–50Brentford2915682957171933–342020–21Brighton & Hove Albion14950142661961–622016–17Bristol City 462218646914231901–022024–25Bristol Rovers16349166731961–621999–2000Burnley 64381214641415351888–892024–25Burton Albion211022002016–172017–18Burton United 321030211901–021903–04Bury4827138481214221895–962012–13Cambridge United10523101271977–781999–2000Cardiff City 50251015501215231921–222024–25Carlisle United16736164661965–662013–14Charlton Athletic34236534117161929–302019–20Chelsea351961035710181907–081980–81Chester City 13454134361975–761995–96Chesterfield24111032477101901–022014–15Colchester United161024162681974–752014–15Coventry City 211380217861949–502024–25Crawley Town320130122012–132014–15Crewe Alexandra14734143471985–862014–15Crystal Palace2010732024141964–652010–11Darlington 632164201925–261995–96Darwen 2200 2101 1891–921893–94Derby County 56321113561310331888–892024–25Doncaster Rovers161033164661901–022014–15Everton441817944128241888–891960–61Exeter City12642124171977–782011–12Fleetwood Town110010102014–152014–15Fulham34157123496191912–132021–22Gainsborough Trinity321031021901–021903–04Gillingham2591332577111970–712014–15Glossop642063121899–19001914–15Grimsby Town29204529712101903–042002–03Halifax Town 531151041970–711986–87Hartlepool United851283231985–862012–13Hereford United 843184311974–751995–96Huddersfield Town45231210451011241912–132023–24Hull City 31223631611141912–132024–25Ipswich Town17863174491964–652023–24Leeds City 220020111912–131914–15Leeds United 2714672796121924–252024–25Leicester City2614842611781901–022023–24Leyton Orient301111830710131912–132014–15Lincoln City181134185671901–021998–99Liverpool3215983268181895–961961–62Luton Town 2517532586111949–502024–25Macclesfield Town101010011998–991998–99Manchester City411671841138201899–19002001–02Manchester United331391133711151892–931960–61Mansfield Town12804125521970–711995–96Middlesbrough 4922121549913271901–022024–25Millwall 35187103576221928–292024–25Milton Keynes Dons505053202011–122015–16Newcastle United38205133897221898–992016–17Newport County422040311981–821984–85Northampton Town14851146261963–641998–99Norwich City 241176246991961–622024–25Nottingham Forest50141818502711121892–932021–22Notts County422796421412161888–892014–15Oldham Athletic2613762674151910–112014–15Oxford United 11524112271968–692024–25Peterborough United12633123361974–752021–22Plymouth Argyle 29151042987141930–312024–25Port Vale231625235991901–022014–15Portsmouth 3819154381310151925–262024–25Queens Park Rangers 2410104248791949–502024–25Reading3219673266201926–272022–23Rochdale841384221970–712014–15Rotherham United28101352858151961–622023–24Scarborough 321032101993–941995–96Scunthorpe United16934166281961–622014–15Sheffield United 5525171355811361893–942024–25Sheffield Wednesday 522914952128321892–932024–25Shrewsbury Town13832136161970–712013–14South Shields 321031201925–261927–28Southampton201064204791925–262023–24Southend United12822124441974–752006–07Stevenage321031202011–122013–14Stockport County13832135351901–022001–02Stoke City 52311011521513241888–892024–25Sunderland 5526151455617321891–922024–25Swansea City 33171243356221925–262024–25Swindon Town15951154381963–642014–15Torquay United742172051970–711995–96Tottenham Hotspur2612682657141909–101960–61Tranmere Rovers12741122551970–712013–14Walsall2516362554161961–622014–15Watford 191072194691969–702024–25West Bromwich Albion 53251414531411281888–892024–25West Ham United14842143291923–242004–05Wigan Athletic211065217771982–832022–23Wimbledon 622260241981–822003–04Wolverhampton Wanderers58281614581511321888–892017–18Wrexham151023153751970–711999–2000Wycombe Wanderers742173311993–942020–21Yeovil Town321031022011–122014–15York City650163121976–771998–99

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