Refsum is a surname. Notable people with the surname include:
Helge Refsum (1897-1976), Norwegian jurist and politician Maja Refsum (1897–1986), Norwegian sculptor and teacher Marie Borge Refsum (born 1927), Norwegian politician Sigvald Bernhard Refsum (1907–1991), Norwegian neurologist Thomas Refsum (1878–1957), Norwegian sport shooter Tor Hermod Refsum (1894–1981), Norwegian painter
See also Refsum disease