The 1945 Notre Dame Fighting Irish football team was an American football team that represented the University of Notre Dame as an independent during the 1945 college football season. In their first and only year under head coach Hugh Devore, the Irish compiled a 7–2–1 record, outscored opponents by a total of 255 to 122, and were ranked No. 9 in the final AP poll. The team won its first five games and was ranked No 2 before tying No. 3 Navy and losing to No. 1 Army in consecutive weeks. They also lost the final game of the season to Great Lakes Navy.
Quarterback and team captain Frank Dancewicz received first-team honors from the Central Press on the 1945 All-America college football team. Guard John Mastrangelo received first-team All-America honors from the International News Service.
The team played its home games at Notre Dame Stadium in Notre Dame, Indiana.
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