Alfred Hassner (; 11 November 1930 – 27 March 2024) was an Israeli organic chemist.
Biography Alfred HassnerHassner in Who's Who in Science and Engineering was born in Cernăuți and spent World War II in hiding while he lost his father; after the war, he returned to study in Vienna and then immigrated to the USA where he continued his studies. In 1983 he moved with his wife Cyd and two children to Israel. Hassner was recently Emeritus Professor at Bar Ilan University.Hassner's page at Bar Ilan Chemistry depertmant He died on 27 March 2024, at the age of 93.Alfred Hassner (1930 – 2024)
Scientific career After a postdoctoral at Harvard University, Hassner joined the University of Colorado Boulder in 1957 where he became a full professor in 1966. In 1975 he was called to State University of New York Binghamton as Leading Professor and in 1983 he moved to Bar Ilan University in Israel. Hassner was visiting professor at the University of Würzburg, Stanford University, the Weizmann Institute of Science, the University of California Berkeley, the University of Nijmegen, the Claude Bernard University Lyon 1, the Indian Institute of Science Bangalore and the Kyushu Institute of Technology.
Research Hassner’s research group has studied: Regioselective additions of pseudohalogens;J. Org. Chem. 1967, 32, 540; J. Org. Chem. 1969, 34, 2628. Stereochemistry of reactions of azidesAccts. Chem. Res. 1971, 4, 9. and organic nitrogen functions; Development of catalystsTetrahed 1978, 34, 2069; Tet, Lett. 1978, 48, 4475; Tet, Lett. 1979, 3811; J. Org. Chem. 2000, 65, 6368. like DMAP for direct esterification of hindered alcohols; Regiochemistry of 3+2 cycloadditionsJ. Org. Chem. 1991, 56, 2775; Synthesis 1997, 309; J. Org. Chem. 1997, 62, 485; Topics Current Chem. 2001, 216, 1; Pure Appl. Chem., 2000, 72, 1671. and of 2+2 ketene olefin cycloadditions;Tetrahedron Lett. 1968, 3921; J. Am. Chem. Soc. 1971, 93, 264. Reaction of 3-member-ring iodonium ions and of nitrilium ionTetrahedron Lett., 1966, 3119; J. Am. Chem. Soc. 1970, 92, 4379; intermediates; Reactions of steroids;J. Org. Chem. 1966, 31, 1363. Organosilanes,J. Am. Chem. Soc. 1980, 102, 1577; Tetrahedron Lett. 1990, 31, 743 Photochemical protection,Synlett 2007, 1071. Medicinal chemistry,Tetrahedron Lett., 1994, 35, 2397; Tetrahedron Lett. 2002, 43, 2529; Carbohydr. Res 2001, 333, 313. electrophilic amination.Tetrahedron Lett. 1982, 23, 699. Hassner’s group pioneered in methodology for synthesis of small ring heterocycles such as aziridines,J. Am. Chem. Soc. 1969, 91, 5046. azirines,J. Am. Chem. Soc. 1968, 90, 2869; J. Org. Chem. 1979, 44, 3861; Heterocycles, 1980, 14, 1517. azetines,J. Am. Chem. Soc. 1971, 93, 2051. as well as of larger ring heterocycles including azepines. Recently they studied TiCl catalyzed reactions.Adv. Synth. Catal. 2014, 356, 2661.
Awards Hassner was the recipient of several awards and honors: von Humboldt Fellow; Lady Davis Fellow; National Cancer Institute Senior Fellow; Killam Award; Fulbright Fellow; Meyerhoff Fellow; Fellow Royal Society of Chemistry; Israel Chemical Society Prize of Excellence. Hassner served on the editorial board of J. Org. Chem.;Journal of Organic Chemistry Org. Prep. Proced. International;Organic Preparations and Procedures International Heterocyclic Commun.; Trends in Org. Chem. and was elected president of the Israel Chemical Society.
Publications Hassner is the author of 320 scientific publications; he was the editor of the scientific series: Advances in Asymmetric Synthesis (JAI press); Small Ring Heterocycles (Wiley); Topics in Heterocyclic Chemistry (Springer).
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