Methamnetamine (also known as methylnaphetamine, MNA, MNT, MNAP, PAL-1046, and MY-10) is a triple monoamine releasing agent of the amphetamine and naphthylaminopropane families. It is the N-methyl analog of the non-neurotoxic experimental drug naphthylaminopropane and the naphthalene analog of methamphetamine. It has been sold online as a designer drug between 2015 and 2016.
Pharmacology Pharmacodynamics Methamnetamine acts as a releasing agent of serotonin, norepinephrine, and dopamine, with EC50 values of 13 nM, 34 nM, and 10 nM, respectively. It is also a lower-potency partial agonist of the serotonin 5-HT2A receptor.
+ Compound Ref d-Amphetamine 6.6–10.2 5.8–24.8 698–1,765 Naphthylaminopropane (NAP; PAL-287) 11.1 12.6 3.4 d-Methamphetamine 12.3–14.3 8.5–40.4 736–1,292 Methylnaphthylaminopropane (MNAP; PAL-1046) 34 10 13 l-Methcathinone 13.1 14.8 1,772 2-Naphthylmethcathinone (BMAPN; βk-MNAP) 94% at 10μM 34 27 d-Ethylamphetamine 28.8 44.1 333.0 Ethylnaphthylaminopropane (ENAP; PAL-1045) 137 46 a 12 a Phenmetrazine 29–50.4 70–131 7,765–>10,000 Naphthylmetrazine (PAL-704) 203 111 (105) Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Footnotes: a is a partial releaser of serotonin ( = 66%) and dopamine ( = 78%). Refs:
Society and culture Legal status Methamnetamine is illegal in Japan.
See also 2-MAPB 5-MAPBT BMAPN Naphthylaminopropane Ethylnaphthylaminopropane Naphthylpropylaminopentane HDEP-28 HDMP-28 Naphyrone WF-23
References