Casco is a surname. Notable people with the surname include:
Agustín Casco (born 1997), Argentine professional footballer Gladys Bernarda Casco (born 1954), Honduran politician Gonzalo Casco (1533–c.1588), Spanish military leader and conquistador in what is now Paraguay Horacio Casco (1886–1931), Argentine fencer and politician who served as mayor of Buenos Aires Juan Casco (born 1945), Paraguayan retired footballer Milton Casco (born 1988), Argentine professional footballer Zelmar Casco (1926–2020), Argentine fencer who competed in the 1964 Olympics
See also Cascos, another surname