Panayiotou (Παναγιώτου; also transcribed as Panagiotou) is a surname of Greek origin. Notable people with the surname include:
Andreas Panayiotou (footballer) (born 1966), Cypriot footballer Andreas Panayiotou Filiotis (born 1995), Cypriot footballer Emilios Panayiotou (born 1992), Cypriot footballer Fidias Panayiotou (born 2000), Cypriot YouTuber Georgios Kyriacos Panayiotou, birth name of George Michael (1963–2016), English singer and songwriter Harry Panayiotou (born 1994), Saint Kitts and Nevis footballer Nicos Panayiotou (born 1970), Cypriot footballer Panayiotis Panayiotou (born 1988), Cypriot footballer
See also Panayiotou v Sony Music Entertainment (UK) Ltd.