The second cabinet of Pieter Botha was formed following his assumption of the position of State President of South Africa on 3 September 1984. It was dissolved on 6 September 1989, after Botha's incapacitation following a stroke in January of that year. After Botha's resignation in February, he was replaced by Chris Heunis as acting state president for the remaining few months of the cabinet's term. Heunis was replaced with Frederik de Klerk, who was elected leader of the National Party on 2 February and inaugurated as state president on 20 September.

Cabinet Ministry/PortfolioMinister/IncumbentPartyPeriodState President of South AfricaPieter BothaChris Heunis NP1984–891989Minister of Agriculture and FisheriesGreyling WentzelNP1984–89Minister of Constitutional Development and PlanningChris HeunisNP1984–89Minister of DefenceMagnus MalanNP1984–89Minister of Economic Affairs and Technology Daniel SteynNP1984–89Minister of Education and CulturePiet ClaseNP1984–89Minister of Environment and Water AffairsGert KotzeNP1984–89Minister of FinanceBarend du PlessisNP1984–89Minister of Foreign AffairsPik BothaNP1984–89Minister of Health and Population Development Willie van Niekerk NP1984–89 Minister of Home Affairs Stoffel Botha NP 1984–19851985–1989Minister of JusticeKobie CoetseeNP1984–89Minister of Law and OrderAdriaan VlokNP1984–89Minister of ManpowerPietie du PlessisNP1984–89Minister of Mining and EnergyDaniel SteynNP1984–89Minister of Posts and TelecommunicationsL.A.P.A. MunnikNP1984–86Minister of Public Works and Land AffairsL.A.P.A. MunnikNP1984–86Minister of Trade and IndustryDawie de VilliersNP1984–89Minister of TransportEli LouwNP1984–89Minister of Indian Affairs Amichand Rajbansi NPP 1984–89Minister of Coloureds' Affairs Allan Hendrickse LP 1984–89

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