Cuffy was an Akan slave in the Dutch colony of Berbice (present-day Guyana) who led a revolt of more than 2,500 slaves in 1763.
Cuffy may also refer to:
Cuffy, a name derived from the Akan name Kofi, meaning "born on a Friday" Cuffy, Cher, a commune of the Cher département, in France Cuffy (TV series), a British sitcom from the early 1980s Cuffy Meigs, a character in Atlas Shrugged
See also Cuffee, an African-American first name and surname also derived from Kofi William Cuffay, a British political activist