Santo André, São Paulo is a Brazilian municipality.
Santo André (Portuguese and Galician for Saint Andrew) may also refer to:
Places Brazil: Santo André, Paraíba, a city
Cape Verde: Santo André (Porto Novo), a civil parish
Portugal: Santo André (Santiago do Cacém), a city Santo André, Póvoa de Varzim, a neighborhood Cape Santo André
Spain: Santo André de Teixido, a pilgrimage sanctuary in Cedeira, Galicia
Other Esporte Clube Santo André, a Brazilian football (soccer) team NRP Santo André, a Portuguese Navy ship 1962–1975, now the museum ship Rickmer Rickmers in Hamburg Navio Museu Santo André, a museum ship in Gafanha da Nazaré, Ílhavo, Portugal