Big Lick may refer to:
Big Lick, North Carolina, a populated place Big Lick, Virginia, a former name of Roanoke A "big lick" gait is an unnaturally exaggerated horse movement of a Tennessee Walking Horse created by illegal soring The HD-2 channel of WCLT-FM, a radio station (100.3 FM) licensed to Newark, Ohio, United States A galaxy group consisting of NGC 5371 and Hickson 68