O'Farrill is a Hispanic surname derived from the Old Irish patronym Ó Fearghail. Notable people with the surname include:
Arturo O'Farrill (born 1960), Mexican musician based in New York, son of Chico Chico O'Farrill (1921–2001), Cuban musician Gonzalo O'Farrill y Herrera (1754–1831), Spanish soldier and politician Rómulo O'Farrill (1917–2006), Mexican businessman Yordan O'Farrill (born 1993), Cuban sprinter