Nepean is a surname. Notable people with the surname include:
Augustus Nepean (1849–1933), Middlesex county cricketer Charles Nepean (1851–1903), Middlesex county cricketer and Oxford University footballer Evan Nepean (1751–1822), British politician and colonial administrator Evan Nepean (cricketer) (1865–1906), Middlesex county cricketer Mary Edith Nepean (1876–1960), Welsh writer Molyneux Hyde Nepean (1783–1856), Middlesex county cricketer and son of Evan Nepean