Negulescu, sometimes Negulesco is a Romanian surname. Notable people with the surname include:
Adrian Negulescu (born 1961), Romanian chess master Ion Negulescu (1887-1949), Romanian general and Minister of War Jean Negulesco, born Negulescu (1900–1993), Romanian-American film director and screenwriter Paul Negulescu, American–Romanian cell biologist Petre P. Negulescu (1870–1951), Romanian philosopher and politician Radu Negulescu (born 1941), Romanian table tennis player
See also