Marchini is a family name of Italian origin. Notable people with the surname include:
Giannina Marchini (1906–1979), Italian sprinter and middle distance runner Davide Marchini (born 1981), Italian football player Jonathan Marchini (born 1973), Bayesian statistician and professor of statistical genomics Libero Marchini (1914–2003), Italian football player Ron Marchini (born 1945), American karateka Simona Marchini (born 1941), Italian actress and presenter Tasso Marchini (1907–1936), Italian Modernist painter
See also Marchi Marchetti