Panella is a surname. Notable people with the surname include:
Clementina Panella, Italian archaeologist Frank Panella (1878–1953), American composer Giovanni Bonifacio Panella (died 1417), Italian Roman Catholic prelate Jack Panella (born 1955), American judge Louis J. Panella (1881–1940), American musician, composer, and teacher Pasquale Panella (born 1950), Italian lyricist and writer Alfredo Panella (1896–?), Italian motorcycle racer
See also Panelli, surname