Del Duca may refer to:

Antonio del Duca (1491–1564), Sicilian friar Cino Del Duca (1899–1967), Italian-born businessman film producer and philanthropist Frank Del Duca (born 1991), American bobsledder Giacomo del Duca (c. 1520–1604), Italian sculptor and architect Marcello Del Duca (born 1950), Italian former water polo player Simone Del Duca (1912–2004), French businesswoman, and major philanthropist, married to Cino Del Duca Sergio Del Duca (born in 1968) Musician (drum player) born in Argentina Steven Del Duca (born c. 1973), Canadian politician and former leader of the Ontario Liberal Party

See also Prix mondial Cino Del Duca, an international literary award Simone and Cino Del Duca Foundation, a charitable foundation based in Paris Stadio Cino e Lillo Del Duca, a multi-purpose stadium in Ascoli Piceno, Italy