Kate O'Brien may refer to: Kate O'Brien (novelist) (1897–1974), Irish novelist and playwright Kate O'Brien (cyclist) (born 1988), Canadian track cyclist and bobsledder Kate Cruise O'Brien (1948–1998), Irish writer Kate O'Brien (The Drew Carey Show), a character from The Drew Carey Show
See also Catherine O'Brien (disambiguation) Cathy O'Brien (disambiguation) Kate O'Brian, founder of O'Media Strategies Katie O'Brien (born 1986), British professional tennis player Katy O'Brien (Fair City character), from the Irish television series Fair City