Ghedina is an Italian surname. Notable people with the surname include:
Bruno Ghedina (1943–2021), Italian ice hockey player Giuseppe Ghedina (1898–1986), Italian cross country skier Guerrino Ghedina (born 1956), Italian Olympic bobsleigh competitor Guido Ghedina (1931–1976), Italian Olympic alpine skier Kristian Ghedina (born 1969), Italian alpine skier Luigi Ghedina (mountain climber) (1924–2009), Italian mountain climber Luigi Ghedina (painter) (1829–1900), Italian decorative painter and decorator Mario Ghedina (1909–1974), Italian architect