4-hydroxy-tetrahydrodipicolinate reductase

4-hydroxy-tetrahydrodipicolinate reductase () is an enzyme that catalyzes the chemical reaction

The three substrates of this enzyme are (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid, reduced nicotinamide adenine dinucleotide (NADH), and a proton. Its products are (S)-2,3,4,5-tetrahydrodipicolinic acid], oxidised NAD+ and water. Nicotinamide adenine dinucleotide phosphate can be used as an alternative cofactor.

This enzyme is part of the biosynthesis pathway to lysine.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ 4-oxidoreductase. Other names in common use include: dihydrodipicolinate reductase, dihydrodipicolinic acid reductase, and 2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase.

References