Altolaguirre is a Spanish surname. he surname is associated with a Basque lineage with ancestral houses in Lazcano and Gaviria; members of the lineage later settled in Argentina, and some belonged to the Order of Santiago and the Order of Charles III.. Notable people with the surname include:
Hernán Altolaguirre (born 1993), Argentine footballer Manuel Altolaguirre (1905–1959), Spanish poet, editor, and publisher Quintín Altolagirre (1876–1936), Spanish doctor, politician, and sports leader