Prioleau is a surname. Notable people with the surname include:
Betsy Prioleau, American non-fiction author. Dijon Prioleau (born 1992), American gospel singer. Edward Prioleau Warren (1856–1937), British architect and geologist. Hamilton Prioleau Bee (1822-1897), American politician. James Prioleau Richards (1894-1979), American politician. Pierson Prioleau (born 1977), American football player. Samuel Prioleau, American politician.
See also John Cordes Prioleau House, a historic mansion in Charleston, South Carolina