Patriarch Sophronius of Alexandria may refer to:
Patriarch Sophronius I of Alexandria, ruled in 841–860 Patriarch Sophronius II of Alexandria, Greek Patriarch of Alexandria in 941 Patriarch Sophronius III of Alexandria, ruled in 1116–1171 Patriarch Sophronius IV of Alexandria, ruled in 1870–1899 (same person than Sophronius III of Constantinople)