DDF may refer to:
Biology and medicine Digestive Disorders Foundation, a British medical research charity (N,N-dimethyl-amino)-benzenediazonium-fluoroborate, a photoaffinity probe that competes with acetylcholine for receptor binding Sulfoxone, an anti-leprosy drug sold under "DDF" brand
Technology Digital distribution frame, a device which terminates digital data streams, allowing arbitrary interconnections to be made 4,4'-Dinitro-3,3'-diazenofuroxan, an experimental high explosive Disk Data Format, a structure describing how data is formatted across disks in a RAID group
Ecology and conservation Deciduous Dipterocarp Forest or Dry Deciduous Forest, also known as dry broadleaf forest, a type of dipterocarp forest found in tropical and subtropical latitudes, particularly India and mainland Southeast Asia.
Other uses DanDoesFooty, an AFL podcast launched in 2024 by Dan Gorringe Demographic Development Fund, Georgian think tank Dicastery for the Doctrine of the Faith, a Rome-based Catholic institution Drop Dead Fred, a 1991 fantasy comedy film Dubai Duty Free, a duty-free retailer