2,4,5-Trihydroxymethamphetamine (THMA-2 or THM) is a neurotoxin and a metabolite of MDMA. It has structural similarity to the dopamine neurotoxin 6-hydroxydopamine, and produces lasting serotonin deficits when administered centrally.

See also 2,4,5-Trihydroxyamphetamine (THA) 3,4-Dihydroxyamphetamine (HHA; α-methyldopamine) 3,4-Dihydroxymethamphetamine (HHMA; α-methylepinine) 4-Hydroxy-3-methoxyamphetamine (HMA) 4-Hydroxy-3-methoxymethamphetamine (HMMA) Methyl-TMA-2 (N-methyl-2,4,5-trimethoxyamphetamine)

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